5 Essential Elements For does methadone cause qt prolongation
[sixty one] Like many other cardiotoxic drugs, methadone blocks the hERG K+ channel. The 2 enantiomers of methadone inhibit hERG channels with distinctive potency. Dextromethadone, which is considerably less strong as an opioid, is more potent at blocking the hERG channel with an IC50 of ~12 μM. Levomethadone incorporates a lower affinity, with an